It can pride itself on a peculiarity of a European scale: the Goth burial places dating from 2nd - 4th century, discovered in Hrubieszów municipality, as well as the chalk tunnels in Chełm. There are many old magnate castles and palaces, gentry residences, noblemen's mansions, among others in Lublin, Kozłówka, Puławy, Radzyń Podlaski, Janowiec, Krupe. They are the reminders of old Polish families: Zamoyski, Lubomirski, Radziwiłł, Czartoryski, Sobieski, Tarnowski, Firlej, Sapieha. The Zamoyski Museum in an old residence of the noble family  in Kozłówka near Lubartów is one of the most popular museums in Poland - in 2003 it welcomed 260 thousand visitors.

At the same time numerous historical religious buildings of various denominations: Catholic and Orthodox churches and former synagogues are an example of the many permeating cultures and of religious tolerance. The region's most notable sacral building is the Gothic Chapel of the Holy Trinity in the Lublin Castle with its interior completely covered with Russo-Byzantine frescos from the beginning of the 15th century. A typical church style of the region is the so-called Polish renaissance, richly decorated with stuccos, examples of which were preserved among others in Lublin, Kazimierz Dolny and Końskowola. In Włodawa there remains one of the most spectacular synagogue complexes in the country and nearby in Jabłeczna there is a sanctuary of St. Onuphrius, an important place for the Orthodox Church.

Apart from single buildings there are also noteworthy architectural complexes: the renaissance Zamość, called "the Padua of the North," one of the UNESCO World Heritage Sites; Kazimierz Dolny, an artists' town on the Vistula, which integrates the landscape and natural assets of the Vistula gorge with the beauty of numerous architectural and artistic monuments; the mediaeval Lublin with its original preserved Old Town. In general, in the area of the Voivodship, there are over 20 thousand catalogued objects of a historic cultural value, among them many unique examples of folk architecture, protected and exhibited among others in the Lublin Open Air Village Museum and other open air museums in Hola, Guciów, Biłgoraj and Zaborek near Janów Podlaski.

Lublin is the cultural centre of the region; other important centres include Biała Podlaska, Puławy, Chełm, Zamość. There are several active theatres, including the Juliusz Osterwa Theatre, the Musical Theatre and the Hans Christian Andersen Theatre. For years the region has  also boasted world-famous alternative theatres: Centre for Theatre Practices Gardzienice (founded and led by Włodzimierz Staniewski), Leszek Mądzik's Artistic Stage of KUL, Provisorium Theatre (lead by Janusz Opryński) or Tomasz Piesiewicz's "Grodzka Gate - NN Theatre" Centre. Lublin hosts theatre events of great importance - the International Festival "Theatre Confrontations" and the International Dance Theatres Festival. Gardzienice invites to the Academy for Theatre Practices, Puławy hosts the National Puppet Artists Meetings and Zamość - "Fortalicje" International Festival of Intuitive Art and Zamość Theatre Summer.

There are almost 40 museums in the region, including the most important Lublin Museum with 10 branches in Lublin, Kraśnik, Lubartów, Łęczna and Nałęczów, as well as the Vistula Museum with several branches in Kazimierz Dolny and Janowiec. The Zamość Muzeum is famous for the richest collection of archaeological relics of the Goths in the country, while the Chełm Museum hosts a valued Modern Art Gallery. The Zamoyski Museum in Kozłówka is famous, apart from interiors of  magnate mansions unique in the Polish scale, from the Socialist-Realist Art Gallery, containing over  1,600 sculptures, paintings, pictures, images, posters and other works of art from the 1950s, engaged in the fight for socialism. The Lublin Philharmonic invites not only to symphonic concerts, but also to meetings with the greatest stars of the Polish musical scene. The musicians perform concerts and recitals both on their own stage in Lublin and outdoors in the Spa Park and in the Małachowski Palace in Nałęczów. Poniatowa has for many years been the home of the famous Children's Early Music Band Scholares Minores Pro Musica Antiqua (founded and lead by Danuta and Witold Danielewicz). Nadrzecze boasts the Foundation Kresy 2000 - Auxiliary House of Art headed by Alicja and Stefan Szmidt. The Lublin region also possesses the largest library net in Poland (about 650 establishments).

Folk art develops splendidly on the basis of rich traditions. In Lublin itself there are many world-renowned folk music bands, among others the MCSU Folk Dance Band, "Jawor" Song and Dance Band of the University of Life Sciences or the Lublin Song and Dance Band. The traditions of folk culture and rituals are cultivated in many places in the region, e.g. around Krzczonów, Urzędów and Biłgoraj. They are protected and popularized by festivals and other events such as the National Folk Bands and Singers Festival and the Folk Art Fair in Kazimierz Dolny,the International Polesie Folklore Summer in Włodawa, the National Meeting of Polish Country Theatres in Tarnogród or the National Blacksmiths Meetings and the National Blacksmithing Art Fair in Wojciechów.